if they have an issue with white colonizers using synthetic Peyote mescaline, is that not also worth consideration and empathy

Edited because I think I misunderstood the argument you’re making. Apologies for being a big dummy.

I can absolutely see why commodifying mescaline or rituals associated with constitutes harmful appropriation of indigenous culture against their expressed desires, but I don’t see why synthesizing (or growing and extracting at home) a substance outside of the context of its traditional use, and using it privately is harmful. Obviously it’s done against the expressed preferences of a culture that has used the chemical for centuries+ but I’m encountering some trouble accepting the notion that a being colonized necessarily prioritizes one people’s spiritual belief over private drug use.

If this also completely misses the argument you’re making, I apologize.