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Scientists in Brazil are developing the first vaccine that could help break cocaine addiction::The vaccine is designed to help produce anti-cocaine antibodies in the body of a person who is chemically dependent on the substance.
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It sounds like this treatment would need close supervision as it appears to only remove the effects of cocaine but not the desire of the effect of cocaine. From the National Institute on Drug Abuse.
“cocaine acts by binding to the dopamine transporter, blocking the removal of dopamine from the synapse. Dopamine then accumulates in the synapse to produce an amplified signal to the receiving neurons. This is what causes the euphoria commonly experienced immediately after taking the drug”
Would people not just chase the equivalent effect from another drug or substance or potentially overdose trying? Do people go through full withdrawal with this treatment? I would presume so.
There’s a similar therapy used sometimes with alcoholics – although in that case, the drug (https://en.m.wikipedia.org/wiki/Disulfiram) doesn’t just block the effects of intoxication, it makes the experience intensely miserable (sometimes even to the point of being life-threatening).
Disulfiram can be quite successful when used correctly, but the success of the treatment largely depends on the patient’s willingness to continue the therapy. I imagine the same will apply with this vaccine.
There are two less extreme medications for alcohol abuse prevention. Naltrexone -also used for opiate cravings, and Campril. Naltrexone also blocks effects of alcohol without making you violently ill, but speaking from experience, enough alcohol can overcome the effect.
I can’t speak to Campril much because it gave me horrible side effects and I had to stop taking it pretty much immediately.
IIRC one of the anti-opiate medicines does the same thing. Any time you consume opiates you get ridiculously sick to the point where it’s just not worth it.
Naltrexone ftw!
This has actually been tried before in a number of different ways, with horrific results because of what your comment addresses.
There was a Soviet drug that would make people violently ill if they drank alcohol. There was a drug from Brazil that would make people ill for cocaine or opiates. Another more recent one from Mexico worked like a Beta Blocker for Cortisol.
You just can’t stop the human body from doing what it is instinctively built to do. You certainly can’t make an addict take a pill every day to stop the reaction.
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I’m proud of you! I’ve known too many people that succumbed to opiates (two cousins on opposite sides of the family, three former roommates at different times, a girlfriend, her friend. “Luckily” only one of them died (permanently, my cousin apparently died but they were able to bring him back).
I fucked around with opiates a lot in college (due to the aforementioned people I lived with and knew) but luckily never got into long term addiction, my body is apparently odd and withdrawal symptoms would kick in the next day if I did more than about 22 mg or so of oxycodone (sounds like an odd number, but it’s about 3/4 of a 30 mg Roxicet), anything less than that and I was fine. I woke up feeling like absolute ass one day and asked my gf (more like an unofficial girlfriend, good friends and fuck buddies) if she had some I could take to test a theory (that I was going through withdrawal), she said she would give me like 5 mg. I snorted that and the shittiness was gone immediately. I immediately was like “well this isn’t good…” but at least I knew what opiate withdrawal felt like… and it’s absolutely fucking miserable. I dealt with it for like a day or so, I can’t imagine being like that for days or weeks on end, after that experience it’s completely obvious why people relapse. I hadnt touched them in about a decade until I had hernia surgery and luckily this isn’t going the way you think it is. I knew my limits (about 12-15 mg to get that nice, warm, buzz and itchy goodness) so I popped three percs… And then felt like shit and puked my guts up, which is exactly what I wanted to do after having a doctor make a 4 inch incision in my lower abdomen. I ended up taking one or two if I really needed it, but it turned out most of the pain was caused by the bandage, and not the surgery itself! Last month I had a nasty case of bronchitis, cough medicine wouldn’t do shit. My mom found percs my dad had from surgery years ago so I started taking them for the cough, which worked wonders. I also enjoyed the high, but once they were gone, I had no urge to do more, which was wonderful.
Just like you said, you have to want to get help otherwise it’s futile. It’s the same with mental health. If you’re being forced into it, you’re not going to put your “all” into it.
I’m assuming you were doing pills because $300 on heroin is a lot of dope. We could get a bundle for like $50-75. 30 mg Roxys were like $25 a pill though.
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Damn man, I feel for you. I just turned 38, and I know the custody struggles. My brother got involved with this girl 8 years younger than him about ten years ago and they dated on and off, always had issues. They willingly had a kid, and then once she was born all hell broke loose and the mother “became” crazy (she was always crazy but hid it well, idk exactly what her issues are, but she’s an only child and she lives with her mom in their trailer even though she’s like 32 and dropped out of high school apparently because people made fun of her voice a lot, it’s kinda high pitched and nasally). She became extremely possessive of her daughter, saying things like “this is my baby!” to my brother, not letting him do things with her while she wasn’t around , and a whole bunch of other shit. My brother isn’t an alcoholic but he does like to drink, he’s had 2 DUIs in the past, and she used that against him constantly. My brother said something he didn’t mean which she considered a threat against life (he was frustrated and said “I’m wanna fucking kill you right now” or something like that, that’s the way he expresses his frustration and has to her in the past I guess). The cops came, found his little bit of weed, 5 registered guns… and an antique pistol that wasn’t registered, which is a felony. He spent 3 days in jail for that shit. After that it was “mother’s rights” so she got to keep the kid in her trailer, instead of my brother’s 1 story house. He had to have surprised visitation for like 2 years, along with probation for like a year. During all of this she even concocted false stories about him and about my mother (the sweetest, most caring person in the world that was a respected special education teacher for 35 years). Long story slightly shorter: they went to court, my mom and brother won, which meant shared custody and he could take her wherever he wanted to without the mother’s permission.
I’m sorry to hear that your daughter lost her mom, but depending on how young she is, and I hate to say this, but it may have been for the better if she had BPD (I’m assuming you mean Borderline, and no BiPolar), because that’s some shit to deal with. My ex had BPD tendencies (fit most of them, except for being promiscuous) and she was friends with my nieces mom, which we always thought was odd since they lived about 2 hours apart, but they were around the same age and talked on Facebook a lot. My ex never hid it, it came out right after we started dating. Luckily I never knocked her up! If I’m reading this correctly you have full custody of her which is awesome, and it’s always great to have another parental figure around.
I end up writing books as well, I get too deep into something, and when I’m done, I’ll look up and be like “I just wrote 5 paragraphs they’re never gonna read this” but most of the time they actually do!
It sounds like you’ve had a hell of a life up until now, but things are finally starting too look up for you, keep your chin up, you got this 😉
I moved down to Miami 2 weeks ago, so things are going pretty good for me at the moment, I just gotta find a job, and tackle this life long insomnia. I just took 20 mg of Ambien and I’m still awake WTF… Usually 15 mg knocks me out whether I want it to or not.
Stay safe buddy, here’s to good things for us 🍻
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Damn man, that’s a lot to deal with, no wonder you had to escape with opiates. I’m not gonna lie, I was tearing up when writing my response to you before and reading that made me tear up as well. I feel for you guys because that shit hurts at a core level, my ex did a number on me, but nothing close to what you and your daughter had to deal with. I’m glad you guys are in a better place now and haven’t decided to hang on to hate and anger.
Yeah the addiction is to dopamine, cocaine is just an easy way to get that fix. Gambling and other lesser addictions give the same dopamine fix, but then there are good addictions that provide the same dopamine hit. None of them are as immediate and as powerful as the old nose candy though (aside from amphetamines).
Some people are hardwired to “love dopamine” more than others (so called “addictive personalities”), so it’s all about replacing a bad addiction with a good one. I have ADHD and it went untreated for nearly 4 decades, I was always the one out of my group of friends that could be like “nah, I’ve had enough coke tonight, my sinuses are on fire and I’m not getting anything more out of it, I’m just wasting money at this point” meanwhile my friends are always like “YOU WANNA DO/GET MORE?!?” 😳 I still get high from it, but I can apparently control myself a lot better than other people.
Addiction is a symptom not a root issue. If the context of someone’s addiction is escapism then this theoretically will just push them to another potentially more harmful method.
For things that are physically addictive, addiction is actually a disease.
They change the way your brain functions and can elevate themselves to the same level as thirst in some cases.
You aren’t wrong that other factors can cause a person to use addictive substances and this won’t help with that.
But many people do addictive substances purely because they get addicted.
In many cases addiction makes your life way worse and the things you do to feed it are horrendous. So this argument doesn’t apply to many.
For things that are physically addictive, addiction is actually a disease.
Cocaine isn’t physically addictive.
You’re absolutely right. I’m surprised by that.
It’s a common misconception, like much information around most illegal drugs.
These things aren’t illegal for any moral reason, it’s purely about money and politics.
If you’re further interested, there’s plenty of info about the administration of heroin by Boots the Chemist in London before it was made illegal. Fascinating stuff.
Heroin was sold in the back of the Sears catalog in the US in the early 1900s! It was marketed to housewives to “take the edge off of a stressful day”.
You’re absolutely right that it’s all about money and politics. It has always amazed me how (in the US) weed is placed in the same schedule (legal tier of how restricted it is) as heroin and cocaine, saying that they’re extremely addictive and have no medical usage… Which is absolute bullshit. We all know cocaine is a stimulant and numbing agent, heroin was invented by Bayer Pharmaceutical and is a strong pain killer, and we’re discovering that weed has many benefits. Also the US government has a patent for the medicinal usage of cannabis… while simultaneously stating that it has no medicinal usage 😶
The UK is said to be the biggest exporter of medical cannabis in the world. The person who owns the largest manufacturer is said to be the husband of the former drug minister Victoria Atkins.
This is all hearsay and tittle tattle of course -
I wouldn’t think of the UK as a good place for growing weed since it’s generally relatively cold and rainy there most of the time isn’t it? That obviously doesn’t matter for hydroponics.
Also the US has zero reason to export its weed, we all consume it within the state it’s grown in.
Yet alcohol is and it’s legal in practically every country! You can go out and buy 5 liters of vodka and go home and get shit faced, but you can’t buy weed legally in a lot of places or cocaine legally pretty much anywhere (except for Portugal).
Sure but I don’t think there is no one who resolved their root cause but still are hooked by their chemical addiction
Pretty neat. I had to laugh at the fact that the US is the top consumer of cocaine, not any of the Central or South American countries where it’s far cheaper. Coke is stupid expensive in most places in the US like $50-90/gram that is maybe 20% pure. At least that’s how it was up in the NYC area. I live in Miami now so I’m sure its a lot better quality down here.
20% pure is insane! Everything around is 70%+ after testing. Why do a drug so insanely impure?! If it doesn’t sheen, that’s just mean. If it’s not a chunk, it’s probably bunk. If it’s not a shiny rock, it’s blimey schlock.
I’m just pulling numbers out of my ass, but it gets cut multiple times, maybe 20-30x times from the time it’s made in a place like Colombia until it gets to a small time dealer in NYC (that’s like 3,000 miles). I’ve never gotten enough for it to be worth testing, but I imagine it’s less than 50% pure from a lot of shitty dealers. They’re just trying to make the most profit.
It’s also all about who you get it from. I bought some a few months ago from a dude my friend knew when I lived up there and it was garbage and was like $80/g. It wasn’t washed well or had a bunch of adulterants in it, it had a strong smell and burned like hell, it made our noses bleed. Another friend who has good connects always gets good stuff, some of the best blow I’ve had (I’m not a conesseur, it’s too damn expensive, but I do it when the opportunity presents itself) and other people who have done the same stuff he gets agree.
Ugh that’s awful. I feel very fortuitous to have randomly found a person with ludicrously good stuff. I have had just weird burning foul smelling powder before and I hated it. I’ll get around to acetone washing it one day.
All of the other stuff I’ve tried is 150-200 per ball, and it arrives as a glistening hard slab instead of powder. It’s almost oiley, and tough to separate without using a heated surface. It smells like petrol (and sometimes bananas, I’m guessing that’s how it arrives here!) It feels like nothing when insufflated and a standard line is way too much for me hahaha
I wish I had stuff that good haha
I wish I could share. We haven’t done it in yeeeears, and randomly we discovered someone we’re close to is… I’ll just say, “in the game more than we knew.”
I had always received it in little chunks/powder before, and it took a lot to feel much. I’m guessing it was stepped on a lot. Burned and such.
This stuff? It’s one big shiny slab that’s like… oily? Waxy almost? I heat up a mirror before putting it down so the particulates don’t stick to each other. All of my tests are off the charts for it (I have a full reagent kit and a purity kit.) Absolutely wild. None of it burns at all. The best stuff smells like bananas—you can tell it was smuggled somewhere with a banana shipment!
Now I just want to try anti-cocaine. 😅
That’s called Heroin (or benzos)
Not quite; you’d just be doubly intoxicated. Benzos or heroin and coke are classic combos. A dopamine antagonist like an antipsychotic would be the closest thing to a cocaine reversal agent. That’s also why coke or speed binges can lead to psychosis; too much dopamine.
I was going more off of the fact that coke is a stimulant and benzos and opiates tend to chill people out and make them fall asleep. I have known people that get stimulated when they take opiates, which is always odd to me.
CJNG in shambles
This is the best summary I could come up with:
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Scientists in Brazil have announced the development of an innovative new vaccine to treat addiction to cocaine and its powerful derivative, crack.
Dubbed “Calixcoca,” the treatment, which has shown promising results in trials on animals, triggers an immune response that blocks cocaine and crack from reaching the brain.
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According to Frederico Garcia, a psychiatrist and coordinator of the project at the Federal University of Minas Gerais in Brazil, if the treatment gets regulatory approval, it would mark the first time cocaine addiction is treated using a vaccine.
Last week, the project won the top prize of €500,000 at the Euro Health Innovation Awards for Latin American medicine which was sponsored by pharmaceutical firm Eurofarma.
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Garcia believes Calixcoca could add an important tool to that regimen by helping patients at critical stages of recovery, such as when they leave rehab.
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The exact target group will depend on the outcome of clinical trials, but is theoretically meant to be recovering addicts “who are off (cocaine) and want to stay that way,” he said.
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The original article contains 538 words, the summary contains 191 words. Saved 64%. I’m a bot and I’m open source!
