I use Android Tiers, Glittertech (no surgery), and Rimatomics. My colonies always end up with just the most insane defenses with super powered androids.
Anyone who makes their way to my colony will find the most lavish place on the rim.
*We may or may not be using human hearts to till our soil.
My current one started with 2 a “pair of livers escaping their tribe” or some nonsense. Low tech and supplies.
I end up keeping a small crew of about 8 to 10 people and save scum whenever one dies because I am a coward.