Part of the problem with using tobacco this way (basically diy dip) is that tobacco leaves themselves contain carcinogenic nitrates that will still have long term health impacts. If you’re going to consume nicotine, it’s best that your source is as close to chemically pure as you can get. Synthetic nicotine is by and large the safest option outside of simply not consuming nicotine in any form. It’s still incredibly addictive and cardiotoxic