Here’s the rules:
1: Post something you have never done that you think many people do. 2: Read the other posts, if you have done that thing, upvote it. If you have not done that thing, downvote it. 3: If you believe the person is lying, call them out on it in a reply. 4: If you are called out, give the full story. 4a: If you see a thread containing the full story, boost the person you think is right and truthful.
Person who has the most upvotes when the thread dies wins.
Indeed, a lot of drugs that are non toxic have tolerance created in the brain, while more toxic drugs have to get processed by the kidneys and liver, which is why the functioning of those organs contributes to tolerance.