On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
(Assuming I stay in the Milky Way.) I’d use Saggitarius A* (the black hole at the centre of the Milky Way).
For directions I’d use coreward/rimward, spinward/trailing and zenith/nadir, as suggested by Winchell Chung.