To those from the Western hemisphere, it’s always fascinating to hear that some homes and businesses from the times of the Greek philosophers still have inhabitants, and then you remember that the Western hemisphere is itself not without its own examples, for example some Mexican villages still have temples from the times of the Mayans.
I couldn’t find the oldest building overall, but the oldest surviving house was built in 1716. While my city was settled earlier, it was essentially a “boom town” of the early Industrial Revolution in the US